Post-doc

Postdoctoral position
Mechanisms of Inflammation

A postdoctoral position is available in Fabio Martinon's laboratory at the Department of Biochemistry, University of Lausanne (UNIL), Switzerland. (http://www.unil.ch/central/en/home.html).

The Department of Biochemistry is part of the Faculty of Biology and Medicine and offers an outstanding environment for a successful postdoctoral career. The research campus is located in Epalinges (north of Lausanne), and is part of the Center of Immunity and Infection (CIIL) that also includes the Ludwig Institute for Cancer Research (LICR) and several groups of the Lausanne University Hospital CHUV. The research focus is on Cell biology, Immunology and Cancer.

A 2 years Post Doctoral position is available in the Laboratory of Microbiology and Host-Pathogen interaction, at the Department of Biosciences- University of Milan- for a highly motivated individual.
The general focus of the project is the interaction between intestinal microbiota and the immune response in inflammatory bowel diseases (IBD).
The project involves translational approaches and a team with expertise in metagenomics, microbial genetics and functional immunology. The candidate will study the evaluation of the molecular mechanism by which specific components of the gut microbiota induce differentiation and activation of pathogenic Th1/17 cells.
Candidates with demonstrated skills and knowledge in cell biology, molecular biology and microbiology techniques are encouraged to apply.
Applicants should have demonstrated scientific productivity, good inter-personal and communication skills, and scientific independence.

A full-time postdoctoral research fellow position is immediately available in my group.
The project entails the functional characterization of a novel leukemia driver and the evaluation of possible therapeutics.

The research will require knowledge of cellular and animal models of leukemia.
Expertise with proteomics, and a wide range of molecular and cellular biology techniques will be highly valued. I'm looking for a strongly motivated, career-oriented individual holding a PhD degree in Biology, Biochemistry or other related disciplines.

Metacaspase-like proteases in photosynthetic unicellular organisms

A post-doctoral fellowship is available in the group of Prof. Christiane Funk, Dept. of Chemistry and Umeå Plant Science Centre (https://www.upsc.se/), Umeå University (http://www.umu.se/), Sweden. The aim of the project is to characterize the structure and function of metacaspase-like proteases in cyanobacteria and unicellular algae.
Cyanobacteria and algae have a potential commercial value as microbial producers of fuel or products with higher value; however, in nature their blooms also are threatening health and industrial benefits. To learn more about the viability of large algal/bacterial cultures we plan to study the family of metacaspases and their homologues in unicellular photosynthetic organisms. Studies will be performed in green algae, cryptophytes and cyanobacteria. The projects are connected to strong research environments at Umeå University and will be managed through regular meetings between the scholar and the involved scientists.

Project title: Insights into the role of DNA break processing factors in maintaining genome stability to target cancer cells

Beginning and duration: April/June 2018 - 1 year, renewable

Description: The ability of cells to detect and properly repair double stranded DNA breaks (DSBs) is essential for maintaining genome stability and preventing cancer development.
Indeed, DSBs are the most cytotoxic forms of DNA damage, because inaccurate DSB repair leads to mutations and/or gross chromosomal rearrangements. A critical step in regulating DSB repair is the processing of its DNA ends. Several factors are involved in this mechanism, which are conserved in all eukaryotes.
Mutations in most of these factors lead to genome instability, cancer and severe human inherited diseases. The candidate will characterize the functional role of some of these factors in human cell lines, in term of DNA repair and checkpoint response.

Mesothelioma, Nanomaterials, Cellular Stress Pathways

The Marciniak group studies the role of stress signalling pathways in human disease (http://www.med.cam.ac.uk/marciniak/). We combine fundamental biochemistry, cell biology and the study of patient samples to identify pathological mechanisms, therapeutic targets and novel therapies (see Dickens et al 2016 FASEBJ, Chambers et al. 2015 eLIFE, Chen et al 2015 eLIFE, van 't Wout E.F.A et al 2015 PLoS Pathogens, van 't Wout E.F.A et al 2014 Hum Mol Genetics for examples). The Marciniak group is based in the Cambridge Institute for Medical Research (http://www.cimr.cam.ac.uk), providing an excellent infrastructure and a vibrant research environment. We are seeking an enthusiastic, dynamic and ambitious post-doctoral fellow, to complement our group and to develop therapeutic approaches for malignant mesothelioma using novel nanomaterials. The vacant post is at Research Associate (Post-Doc) level and so a PhD in a relevant discipline is required. Experience with cancer cell biology, proteomics, and/or nanomaterials are highly desirable.

Applications open for postdoctoral fellowships at Leiden University Medical Center in the Netherlands as part of the 'Leading Fellows Postdoc Programme'

The Leading Fellows programme. Leiden University Medical Center takes part in the 'Leading Fellows' Marie Skłodowska-Curie program, specifically aimed at our region. This program will cover 90 fellowships for postdoctoral researchers from all over the world in the next two years. Candidates within 60 months from obtaining a PhD degree are invited to propose research projects exploiting their own strengths and the infrastructure and expertise of the host labs. See: https://www.lumc.nl/research/leading-fellows/ The current call within this program has 40 fellowships available, offering attractive working conditions for projects that last 24 months. We encourage motivated postdoc candidates to apply for a fellowship in the context of ubiquitin and ubiquitin-like signaling.

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