Università degli Studi di Trento, Centre for Integrative Biology - CIBIO: 3-years Post-doc position: Profiling 3D Chromatin topology changes during breast cancer progression

The project
Within the framework of the H2020-RIA "PROCHIP" consortium, the project is centered on determining the contribution of epigenetic reprogramming on the chromatin organization occurring during tumor progression and metastasis formation. Defining the 3D-organization of cancer-associated chromatin domains at single cell level represents a new frontier to decipher tumor heterogeneity and cancer cell plasticity. By using cutting edge technologies in chromatin biology and super-resolution imaging, the herein program aims to solve chromatin domains to gain insights on epigenetic plasticity and its impact to predict the best therapeutic options at different stages of tumor progression. For a project based on multidisciplinary approaches, we are looking for a Post-Doc with a strong research background, experience in the chromatin field and/or super-resolution imaging and a proven publication record. His/Her project will benefit from working within an interdisciplinary framework of five European research groups, favoring cross-contamination of ideas and research discussions.

Project I - Serine Ubiquitination
We are looking for a structural biologist (ideally with some electron microscopy experience) to study novel enzymes regulating phosphoribose-dependent serine ubiquitination (Bhogaraju et al, Cell, 2016; Kalayil et al, Nature, 2018).
The project will be centered around a structural biology approach to study Ub ligase complexes and newly identified Phosphoribose-DUBs.

Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal

The iMM – Instituto de Medicina Molecular João Lobo Antunes is a leading Portuguese private non-­‐profit research institute that offers a vibrant scientific environment, aiming to nurture innovative ideas in basic, clinical and translational Biomedical Research. Created in 2002, iMM Lisboa has established itself as a leading national and internationally competitive biomedical institute. Its strategy has been defined by promotion of excellence, leveraged by high-­‐quality human resources, increasing expenditure in infrastructures and knowledge transfer to the society.

Van Wijk lab – Section of Plant Biology, School for Integrative Plant Sciences

Background: Protein amino (N) termini are prone to modifications and are major determinants of protein stability in bacteria, eukaryotes, and perhaps also in plant chloroplasts. The role of the N-terminus in protein stability is conceptualized in the N-end rule, which states that certain amino acids, when exposed at the N-terminus of a protein, act as triggers (degrons) for degradation. Based on several types of indirect experimental evidence, the presence of the Clp protease system including a ClpS homolog, as well as evolutionary arguments, we postulate that an N-end rule in plastids must exist. This project will build a quantitative reporter system to directly test possible N-degrons in chloroplasts and the involvement of chloroplast ClpS1 and the Clp protease and chaperone system in Arabidopsis.

The Institute of Genetics and Development of Rennes (IGDR) is a multi-disciplinary biological research institute affiliated with the National Center for Scientific Research (CNRS), located on the campus of the University of Rennes in the capital of the Brittany Region in France. The IGDR offers a unique scientific environment that covers research in genetics and genomics, epigenetic regulation, cell and developmental biology, and structural biology.
We are opening a position for an outstanding junior scientist who wishes to establish an independent research group to address cutting-edge biological questions, in particular those related to the interests of the institute.

A post-doctoral position funded for 2 years is available in our group. We study epigenetic regulators in mammalian cells; more precisely we are interested in the modifications of DNA (methylation, hydroxymethylation, ...), the proteins that recognize epigenetically modified DNA, and the functional consequences of these phenomena.

The funded project investigates the dynamics of DNA remethylation in mammalian cells during DNA replication. More specifically, the project focuses on UHRF1, an essential protein that promotes epigenetic memory. We have identified a new mechanism by which UHRF1 is recruited to replicating DNA (Ferry et al Mol Cell 2017). We now wish to expand these findings and systematically identify the mechanisms promoting DNA methylation maintenance on the two replicating strands of DNA. The methods employed include cell culture, CRISPR mutagenesis, whole-genome methylation analyses, proteomics, and live-cell imaging.

Two full-time positions, initially for 6 months, renewable up to the end of the project are available for a highly motivated post-doc to join our multidisciplinary team including researchers and clinicians. Selection will begin now until end of June to start in September 2018 but will continue until the right post-doc is found. To apply, send your CV, a motivation letter and the name of 3 referees, to Questo indirizzo email è protetto dagli spambots. E' necessario abilitare JavaScript per vederlo. or Questo indirizzo email è protetto dagli spambots. E' necessario abilitare JavaScript per vederlo.

Project summary
Miguel Seabra laboratory focuses on the molecular mechanisms involved in hereditary and age-related retinal degeneration. We are seeking two highly talented and motivated postdocs to work on two projects aiming to study:
a) Lysosome dysfunction in age-macular degeneration using cellular and animal models;
b) Recovering neurofunction and promoting neuroprotection in diabetic retinopathy by studying the role of synucleins in retinal degeneration in animal models.
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