University Medical Center Goettingen, Germany
In the laboratory of Prof. Tiago Outeiro
Protein misfolding and aggregation are associated with various neurodegenerative disorders, such as Parkinson's, Alzheimer's, or Huntington's disease. However, whether protein aggregation causes disease or is simply a cellular response to the malfunction of cellular quality control systems is still unclear.
We aim to decipher the molecular mechanisms involved in protein aggregation and neurodegeneration, using a combination of cell-based, together with super-resolution imaging approaches such as STED/STORM and expansion microscopy. We will also use biochemical analyses of protein complexes, along with genetic manipulation and small molecule screens, to identify novel targets for therapeutic intervention in these devastating neurodegenerative conditions.
Within the new Collaborative Research Centre "Quantitative Synaptology" we will decipher the major alpha-synuclein-related alterations in the Parkinson's disease synapse.
Therefore we are looking for a highly motivated and dedicated candidate, willing to work in a team of international coworkers within the excellent environment of the Göttingen research campus and to interact with international collaborators in Europe as well as in North and South America.
Candidates should hold a PhD degree in life sciences (biochemistry, biology, neuroscience, etc). Applications should include a letter of motivation, a CV including list of publications (if applicable), and names and contacts of references familiar with the candidate.