The iMM – Instituto de Medicina Molecular João Lobo Antunes is a leading Portuguese private non-‐profit research institute that offers a vibrant scientific environment, aiming to nurture innovative ideas in basic, clinical and translational Biomedical Research. Created in 2002, iMM Lisboa has established itself as a leading national and internationally competitive biomedical institute. Its strategy has been defined by promotion of excellence, leveraged by high-‐quality human resources, increasing expenditure in infrastructures and knowledge transfer to the society.
At this moment, iMM is looking for a Post Doctoral Researcher to join the 'Telomeres, long noncoding RNAs and genome stability' Laboratory, coordinated by Claus M. Azzalin, PhD (https://imm.medicina.ulisboa.pt/pt/investigacao/laboratorios/azzalin-‐claus-‐m-‐lab/), under the research project "TERRA and telomerase-‐mediated telomere elongation: unveiling novel molecular pathways towards the development of innovative therapeutic approaches for cancer treatment".
The project aims at understanding the functional connections between the long noncoding RNA TERRA and telomerase-‐mediated telomere elongation in human cancer cells. More specifically, the project intends to establish molecular biology based approaches to analyze the cellular levels of the TERRA as well as its post-‐transcriptional modifications; to employ CRISPR/Cas9-‐based tools to produce rapid telomere shortening in human cancer cells; to analyze the effects that TERRA alterations exert on telomerase-‐ mediated elongation of telomeres. Experience in cell biology, biochemistry, RNA biology and molecular biology are required. Additionally, publications in peer-‐reviewed journal will be positively evaluated.
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