Project I - Serine Ubiquitination
We are looking for a structural biologist (ideally with some electron microscopy experience) to study novel enzymes regulating phosphoribose-dependent serine ubiquitination (Bhogaraju et al, Cell, 2016; Kalayil et al, Nature, 2018).
The project will be centered around a structural biology approach to study Ub ligase complexes and newly identified Phosphoribose-DUBs.
Project II - ER-phagy
We are looking for a cell biologist to study the role of ER-phagy receptors in the maintenance and remodelling of the endoplasmic reticulum (Khaminets et al, Nature, 2015; Grumati et al, eLife, 2017). The focus of the project will be on cell biological approaches and Crisper screens and the project will be complemented by mouse genetic models.
Project III - DNA-protein crosslinks in cancer pathogenesis
We are looking for an MD or PhD to study the role of SPRTN protease in maintenance of genome stability, responses to replication stress caused by covalent DPCs, and cancer development (Lessel et al, Nat Genetics, 2014; Lopez-Mosqueda et al, eLife, 2016). The project will involve cell and molecular biological as well as genetic approaches to study already established mouse models with Sprtn mutations causing early onset liver cancer in humans.
Applicants should have a PhD in biology, biochemistry, cell biology or a related subject. For project III, also MD scientists with a keen interest in life science research are welcome to apply. We are searching for ambitious and dedicated candidates who are self-driven, highly motivated and able to work independently as well as part of a team.
Formal applications, including a CV, the names and contact details of three referees and a concise description of research interests and future plans should be addressed to: Ivan Dikic, Institute of Biochemistry II, University Hospital - Building 75, Theodor- Stern-Kai 7, 60590 Frankfurt am Main, Germany
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