Project title: Insights into the role of DNA break processing factors in maintaining genome stability to target cancer cells
Beginning and duration: April/June 2018 - 1 year, renewable
Description: The ability of cells to detect and properly repair double stranded DNA breaks (DSBs) is essential for maintaining genome stability and preventing cancer development.
Indeed, DSBs are the most cytotoxic forms of DNA damage, because inaccurate DSB repair leads to mutations and/or gross chromosomal rearrangements. A critical step in regulating DSB repair is the processing of its DNA ends. Several factors are involved in this mechanism, which are conserved in all eukaryotes.
Mutations in most of these factors lead to genome instability, cancer and severe human inherited diseases. The candidate will characterize the functional role of some of these factors in human cell lines, in term of DNA repair and checkpoint response.
Mesothelioma, Nanomaterials, Cellular Stress Pathways
The Marciniak group studies the role of stress signalling pathways in human disease (http://www.med.cam.ac.uk/marciniak/). We combine fundamental biochemistry, cell biology and the study of patient samples to identify pathological mechanisms, therapeutic targets and novel therapies (see Dickens et al 2016 FASEBJ, Chambers et al. 2015 eLIFE, Chen et al 2015 eLIFE, van 't Wout E.F.A et al 2015 PLoS Pathogens, van 't Wout E.F.A et al 2014 Hum Mol Genetics for examples). The Marciniak group is based in the Cambridge Institute for Medical Research (http://www.cimr.cam.ac.uk), providing an excellent infrastructure and a vibrant research environment. We are seeking an enthusiastic, dynamic and ambitious post-doctoral fellow, to complement our group and to develop therapeutic approaches for malignant mesothelioma using novel nanomaterials. The vacant post is at Research Associate (Post-Doc) level and so a PhD in a relevant discipline is required. Experience with cancer cell biology, proteomics, and/or nanomaterials are highly desirable.
Applications open for postdoctoral fellowships at Leiden University Medical Center in the Netherlands as part of the 'Leading Fellows Postdoc Programme'
The Leading Fellows programme. Leiden University Medical Center takes part in the 'Leading Fellows' Marie Skłodowska-Curie program, specifically aimed at our region. This program will cover 90 fellowships for postdoctoral researchers from all over the world in the next two years. Candidates within 60 months from obtaining a PhD degree are invited to propose research projects exploiting their own strengths and the infrastructure and expertise of the host labs. See: https://www.lumc.nl/research/leading-fellows/ The current call within this program has 40 fellowships available, offering attractive working conditions for projects that last 24 months. We encourage motivated postdoc candidates to apply for a fellowship in the context of ubiquitin and ubiquitin-like signaling.
A postdoctoral position in "Molecular processes relevant for Amyotrophic Lateral Sclerosis (ALS) initiation and progression" will be available in the Center for Life Nanoscience at Istituto Italiano di Tecnologia (CLNS@SAPIENZA, Rome, Italy).
Candidates should have a PhD in Molecular Biology or Cell Biology or Biochemistry.
Please apply before: November 30, 2017.
INFO: Web site
Postdoctoral positions are available for highly motivated Ph.D. and/or M.D. to work on host cell reprogramming by human tumor viruses. We study the mechanisms by which oncogenic herpesviruses interfere with cellular functions regulated by ubiquitin and ubiquitin-like post-translational modifications and the role of virus-induced DNA damage and genomic instability in oncogenesis.
For examples of recent publications on the subject see: Gastaldello et al. Nature Cell Biol. 2010, 12:351-61; Kamranvar & Masucci Luekemia 2011, 25:1017-25; Gastaldello et al. J Mol Cell Biol. 2012 4:242-51; Coppotelli et al. Nucleic Acids Res. 2013, 41:2950-62. Gastaldello et al. PLoSPathog 2013 9(10):e1003664; Chen et al. Oncogene. 2016 doi: 10.1038/onc.2015.450; Li et al. PLoS Pathog. 2017 Apr 17;13(4):e1006338.
University Medical Center Goettingen, Germany
In the laboratory of Prof. Tiago Outeiro
Protein misfolding and aggregation are associated with various neurodegenerative disorders, such as Parkinson's, Alzheimer's, or Huntington's disease. However, whether protein aggregation causes disease or is simply a cellular response to the malfunction of cellular quality control systems is still unclear.
A postdoctoral position is available at the Department of Biotechnology and Bioscience (University of Milano-Bicocca, Milano) for a research project on personalized cancer medicine, in the frame of EU (ITFoC, FlagEra project), and coordinated by Prof. Marco Vanoni.
The project involves analysis of metabolic set-up of patient-derived samples, cell lines, tumor organoids and xenotrasplants of breast cancer patients, integration in computer models to predict drug sensitivity and preclinical validation of model prediction on patient derived cancer model systems.