Clonal selection is a major mechanism through which tumor cells succeed in adapting to severe envi-ronmental changes and maintain their fitness.
This Darwinian process of tumor evolution is bound to generate heterogeneous profiles of driver mutations within a single lesion and across different lesions in any individual patient (intra-tumor heterogeneity).
On the other hand, tumors with the same histo-type isolated from different patients may diverge substantially in their profile of genetic drivers (inter-tumor heterogeneity) and yet share relatively homogeneous gene expression profiles and, predicta-bly, the unique biological and clinical features inherent to those shared transcriptional programs. The-se compound patterns of tumor heterogeneity pose a potential challenge to a notion of precision can-cer medicine predicated solely upon therapeutic targeting of a unique genetic driver in any individual patient.
The aim of this workshop is to critically appraise these emerging issues by a) presenting a sta-te of the art view of cancer genomic heterogeneity; b) illustrating how this knowledge can be effecti-vely leveraged for pharmacological tumor targeting in the clinic; c) showcasing examples of how com-putational systems biology and functional genomics can be exploited for identifying novel functional dependencies in cancer cells.

| Download Program |

Biology meets Computer Science and Engineering,
University of Cambridge, UK, July 17 to 21, 2017

• Call for Participation and Abstracts Deadline: March 31, 2017
• Early Registration: May 10, 2017
• Late Registration: May 11 - July 21, 2017

The Synthetic and Systems Biology Summer School (SSBSS) is a full-immersion five-day residential summer school at the Robinson College, University of Cambridge, UK on cutting-edge advances in systems and synthetic biology with lectures delivered by world-renowned experts. The school provides a stimulating environment for students (from Master students to PhD students), Post-Docs, early career researches, academics and industry leaders. Participants will also have the chance to present their results, and to interact with their peers, in a friendly and constructive environment.

Martedì, 05 Luglio 2016 00:00

DAMPs 2016

Workshop in Guanajuato, México, November 6-11, 2016
DAMPs 2016 - Injury Perception and Immunity Across the Tree of Life

Organizing Team
Prof. Polly Matzinger, National Institute of Health (NIH), Bethesda, MD, USA
Prof. Walter G. Land, Laboratory of Excellence Transplantex, University of Strasbourg, France
Dr. Martin Heil, CINVESTAV, Irapuato, México.
Dra. Graciela García-Guzmán, UNAM, Mexico City, México.

We use cookies to improve our website and your experience when using it. Cookies used for the essential operation of the site have already been set. To find out more about the cookies we use and how to delete them, see our privacy policy.

I accept cookies from this site.

EU Cookie Directive Module Information