Martedì, 05 Maggio 2015 00:00

Allosteric Pharmacology

ACCADEMIA NAZIONALE DEI LINCEI - FONDAZIONE «GUIDO DONEGANI»
INTERNATIONAL CONFERENCE
18 may 2015
Scientific-Organizing Committee:
M. BRUNORI (Chair), S. CALIFANO, S. CARRÀ, J.-P. CHANGEUX, G. MARINO, F. PALMIERI, S. PONTREMOLI, R. UGO

PROGRAMME

Monday, 18 May
09.00 Welcome addresses: Lamberto MAFFEI, President of the Accademia dei Lincei, and Renato UGO (Linceo, Milano)
09.15 Maurizio BRUNORI (Linceo, Sapienza-Università di Roma): Hemoglobin, an honorary enzyme Session 1 - Chair: Maurizio BRUNORI (Linceo, Roma) - Renato UGO (Linceo, Milano)
09.30 Jean-Pierre CHANGEUX (Institut Pasteur, Paris): Allosteric mechanisms of signal transduction and the modulation of higher brain functions: consequences for drug design
10.15 Joseph SCHLESSINGER (Yale University): Allosteric regulation and inhibition of receptor tyrosine kinase in cancer therapy
11.00 Break

Session 2 - Chair: Gennaro MARINO (Linceo, Napoli) - Sandro PONTREMOLI (Linceo, Genova)
11.30 Vincenzo DI MARZO (CNR, Napoli): CB1 receptors and TRPV1 channels: two different (and connected) ways of being allosterically modulated
12.15 Craig W. LINDSLEY (Vanderbilt University, Nashville): Allosteric modulation of GPCRs for probe and drug discovery
13.00 End of the morning session

Session 3 - Chair: Salvatore CALIFANO (Linceo, Firenze) - Sergio CARRÀ (Linceo, Milano)
14.15 Marcello ALLEGRETTI (Dompé Farmaceutici, L'Aquila): Allosteric inhibitors of chemoattractant receptors: opportunities and pitfalls in drug discovery
15.00 Dino MORAS (Université de Strasbourg): Allosteric controls of nuclear receptors activity
15.45 Break

Session 4 - Chair: Jean-Pierre CHANGEUX (Linceo, Parigi) - Ferdinando PALMIERI (Linceo, Bari)
16.00 Maurizio BOTTA (Università di Siena): Allosteric inhibitors drug design: successful examples in the fields of HIV and cancer
16.45 Eva ESTÉBANEZ-PERPIÑÁ (Universitat de Barcelona): Allostery in nuclear receptors: functional implications and potential biomedical applications
17.30 The FEBS Lecture by Sir John E. WALKER (Nobel laureate, MRC, Cambridge): Allosteric interaction in the mechanism of ATP synthase
18.30 End of meeting

After dinner speech by Claude DEBRU (École Normale Supérieure, Paris) : The philosophical implications of molecular biology and allosterism - Only by invitation

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