Lunedì, 27 Luglio 2015 00:00

PI3K-like protein kinases

Cellular responses to DNA damage and other forms of cell stress are frequently mediated though a set of phosphoinositol-3-kinase-related kinases, including ATM, ATR, DNA-PK and mTOR. Individually and in combination these kinases control cascades of cell signaling that control such diverse processes as mitosis, DNA replication, DNA repair, protein synthesis, protein degradation and apoptosis. Recent observations have contributed to connect the DNA damage response with non-nuclear events such as metabolic reactions and cytoskeleton dynamics, which are also controlled by phosphoinositol-3-kinase-related kinases. Although some of these kinases are discussed at meetings on DNA damage or other meetings about protein synthesis and degradation, and still others on apoptosis, these topics are almost never gathered under one umbrella.

This meeting will gather together the leading figures studying different PI3K-related kinases with the aim of forging new connections among these usually separate fields.

Organizers: James Haber (Brandeis University, US), Marco Foiani (IFOM, Italy) and Michael Hall (University of Basel, Switzerland)


Program summary November 3, 2015
15:00 - Registration
16:00 - scientific session
18:00 - Poster session and drinks reception

November 4, 2015
09:00 - scientific sessions
18:00 - Poster session and drinks reception
20:00 - Conference dinner

November 5, 2015
09:00 - Scientific sessions
16:00 - Closer

* Please note, the above times are provisional. The full meeting program will be available shortly.

Invited speakers

Confirmed speakers

Jiri Bartek (Danish Cancer Society, Denmark)

John Blenis (Weill Cornell Medical College, US)

Vincenzo Costanzo (IFOM, Italy)
Novel functions for ATM and ATR kinases in vertebrate cells

Claudio De Virgilio (University of Fribourg, Switzerland)
Regulation of TORC1 by the EGO complex

David Fruman (University of California - Irvine, US)
Revisiting the mechanism by which rapamycin blocks lymphocyte proliferation

Susan Gasser (Friedrich Miescher Institute, Switzerland)
Regulating Mec1/ATR in S phases

Thanos Halazonetis (University of Geneva, Switzerland)
Mechanisms of oncogene-induced DNA replication stress

Steve Jackson (University of Cambridge, UK)

Susan Lees-Miller (University of Calgary, Canada)
Roles of DNA-PK in DNA repair and mitosis

Robbie Loewith (University of Geneva, Switzerland)
Structural Insights into TORC functions

Maria Pia Longhese (University of Milano-Bicocca, Italy)
Roles of Mec1 and Tel1 at DNA double-strand breaks

Linda Partridge (Max Planck Institute for Biology of Ageing, Germany)
Nutrient-sensing pathways and ageing

Yossi Shiloh (Tel Aviv University, Israel)
PIKK relationships in the cellular response to genotoxic stress

Cheryl Walker (Texas A&M Health Science Center, US)
PIKK-ing out the Peroxisome: role of ATM and mTORC1 in selective autophagy of peroxisomes (pexophagy) in response to ROS

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