Martedì, 30 Giugno 2015 00:00

Postdoctoral Position – Autoimmunity

One position for a Post-Doct is available at the University of Milano-Bicocca, to carry out research on Innate Immunity Regulation in Autoimmunity. Candidates must have completed their master's degree no more than four years before the date of application.

Autoimmune diseases (AID) such as Multiple Sclerosis (MS), Type I Diabetes and Inflammatory Bowel Diseases are debilitating diseases affecting millions of people worldwide. Accurate and timely diagnosis is needed for effective treatment of the disease but is very difficult since many other inflammatory-based diseases and healthy conditions share symptoms with Autoimmunity.
The goal of the research in this area is to develop a blood-based diagnostic for AID. We have used expression profiling to identify a diagnostic signature that retrospectively identifies different MS phenotypes. Our goal is now to validate this signature and to set up in vitro and in vivo systems by using CRISPR/CAS9 technology. A second Research area of interest is to study Epigenetics contribution to disease development. Because the experimental approach is based on measurements underlying pathophysiology of MS, new pharmaceutical targets may also be found.

The selected Post-Doctoral Fellow will be involved in projects addressing currently poorly understood aspects of Innate Immunity Regulation in Autoimmune Diseases.
We are looking for candidates with a PhD or MD/PhD and a strong background in immunology. Experience with molecular, cellular and multi-color FACS analysis is essential for this position. Hand on experience with transcriptome approaches an mouse models is of advantage. Execution of the project will involve mastering a variety of biochemical, molecular, and cellular techniques.

Interested candidates should submit the following documents to Maria Foti at
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CV
List of publications
Name and contact of two referees
Cover letter detailing motivation for postgraduate study

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