Posizione aperte da ricercatore a Human Technopole

  • 03 Sep 2020

Research Group Leaders in Computational Biology - Neurogenomics Research Centre

The Research Centre for Neurogenomics is seeking outstanding early career researchers to establish their independent groups in computational biology applied to brain disorders. They will be active researchers carrying out high-quality, internationally competitive research and contributors to the international scientific community. The HT Research Centre for Neurogenomics focuses on the dynamics of brain disorders, both neurodevelopmental and neurodegenerative, with a strong emphasis on human experimental models and straddling multiple scales of analysis from single cell resolution to organismal function. The Centre offers an outstanding research environment, including a transformative facility for reprogramming and brain organoids automation, state of the art Genomics and Light Microscopy infrastructures along with a HT-wide architecture of high performance computing (HPC) attuned to the needs of contemporary computational biology and data science. A strategic priority is represented by candidates with experience and an active research program in single-cell multiomics integration and multilayered analysis of datasets derived from large cohorts of brain disorders. Newly appointed Group Leaders will be offered a generous start-up package and core funding. The Research Group Leaders will be responsible for developing their independent research within the Centre, as well as contributing to the collegial development of the HT research programme.

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Research Group Leaders in Experimental Neurobiology - Neurogenomics Research Centre

The Research Centre for Neurogenomics is seeking outstanding early career researchers to establish their independent laboratories investigating neuropsychiatric and/or neurological conditions. They will be active researchers carrying out high-quality, internationally competitive research and contributors to the international scientific community. The Centre focuses on the dynamics of brain disorders, both neurodevelopmental and neurodegenerative, with a strong emphasis on human experimental models and straddling multiple scales of analysis from single cell resolution to organismal function. The Centre offers an outstanding research environment, including a transformative facility for cell reprogramming and brain organoid culture and analysis automation, leading edge Genomics, Light Microscopy and animal research infrastructures along with an HT-wide architecture of high performance computing (HPC) attuned to the needs of contemporary computational biology and data science. A strategic priority is represented by candidates spearheading patient-specific disease modelling , especially through brain organoids and at single-cell omic resolution. Newly appointed Group Leaders will be offered a generous start-up package and core funding. The Research Group Leaders will be responsible for developing their independent research within the Centre, as well as contributing to the collegial development of the HT research programme.

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Research Group Leaders for the Human Technopole Centre of Genomics - Functional Genomics Programme

We are seeking talented, preferably early career, researchers to establish their independent laboratory at the HT Centre for Functional Genomics. Exceptionally, we will also consider mid-career leading scientist that are considering to move to HT. The Research Group Leaders will be responsible for developing an independent scientific programme within the Centre, as well as contributing to the collegial development of the HT research programme. They will be active researchers carrying out high-quality, internationally competitive research and contributors to the international scientific community. The mission of Functional Genomics in the Centre will be to elucidate key questions including “how the genome is regulated in each cell, tissue and organ in health and disease”, “what are the molecules and networks that drive biological activity in cells, tissues, organs”, and “how to modify genome regulation and genome output in health and diseases”. In particular, we will identify and characterize functional and regulatory non-coding genomic element networks in different cells and tissues of the human body, with the goal to identify the grammar of the genome, which will ultimately provide deeper understanding of genome function and enable genomics medicine. In order to address these challenges, the Centre will develop original technologies to identify and functionally characterize regulatory elements, non-coding RNA (with focus on lncRNAs), the genome conformation and interactomes of biological molecules in living cells. These approaches will be broadly used to map the function and regulation of human genome in health and disease across human diversity.

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Research Group Leaders for the Human Technopole Centre of Genomics - Population and Medical Genomics Programme

We are seeking talented, preferably early career, researchers to establish their independent laboratory in Population and Medical Genomics within the Centre. Strong defining components of this research programme will be the reliance on genomic technologies for large-scale explorations of human traits and diseases, the deep functional characterisation through in vivo and in vitro experiments, and the use of computational and quantitative approaches for data analysis. Exceptionally, we will also consider mid-career leading scientist that are considering to move to HT. The Research Group Leaders will be responsible for developing an independent scientific programme within the Centre for Genomics, as well as contributing to the collegial development of the entire HT research programme.
We envisage a seamless interlinking with activities of the Centres of Functional Genomics, Neurogenomics and Computational Biology wherever relevant. The candidates will be active researchers carrying out high-quality, internationally competitive research and contributors to the international scientific community.
The mission of HT’s work in Population and Medical Genomics will be to advance understanding of genetic factors contributing to human health and diseases. Harnessing the depth of Italian population and its biomedical variability, we will seek to understand “what are the genetic factors underpinning variation in biomedical traits in the general population”, ”through which molecular and functional mechanisms do these genetic variants exert their effect”, “which of these genes and mechanisms point to potential new therapies”. Specifically, through new genomic initiatives we will generate exhaustive catalogues of genetic variation in health and selected disease collections, and characterise their function, thus informing the discovery of interventions tailored to the Italian population.
In order address these challenges, we will deploy scalable genomic technologies for large-scale explorations of human traits and diseases, in vivo and in vitro experiments for the deep functional characterisation of genetic variation, and computational and quantitative approaches for data analysis.

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